Ursodeoxycholic acid dissolution of gallstones in cystic fibrosis

Ursodeoxycholic acid dissolution of gallstones in cystic fibrosis.

The dissolution of cholesterol gall stones is documented in two adults with cystic fibrosis. Improved care of patients with cystic fibrosis has meant that most survive into adult life. Consequently extrathoracic complications are assuming greater importance, especially those of the hepatobiliary system. These include progressive biliary cirrhosis (25%) leading to portal hypertension and oesopha...

New Cochrane Library Systematic Reviews on Cystic Fibrosis Ursodeoxycholic acid for cystic fibrosis-related liver disease

Introduction: Lung function, nutritional status, and parameters of exercise capacity are known predictors of mortality in patients with cystic fibrosis (CF). The aim of the current study was to use these important parameters to develop a multivariate model to predict mortality in adolescent patients with CF. Methods: A total of 127 adolescents with CF (57 girls) with a mean age of 12.7 ± 0.9 yr...

Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans

Background/Aims. The aim of this study was to compare the effects of ursodeoxycholic acid (UDCA) alone and UDCA plus domperidone on dissolution of solitary or multiple gallstones. Methods. Fifty-three patients with cholesterol gallstones were randomized into three treatment groups: group I (n = 22) was given UDCA (15 mg/kg/day) alone and group II (n = 18) was treated with domperidone (30 mg/day...

 The effect of ursodeoxycholic acid in cystic cholangiopathies.

Prevalence of Cystic Fibrosis Trans-membrane Conductance Regulator Gene common mutations in children with cystic fibrosis in Isfahan, Iran

Background: Cystic fibrosis (CF) is the most common lethal genetic disorder of Cystic Fibrosis Trans-membrane Conductance (CFTR) Regulator gene mutations. We aimed to investigate common mutations in CF patients and to assess its possible relationship with clinical presentations. Materials and Methods: This cross sectional study was conducted on 36 CF patients who were referred to a tertiary ped...